Call 833-KK-CARES (833-552-2737) Monday through Friday, 8 AM to 8 PM (ET),
to speak with a Kyowa Kirin Cares Case Manager

Actor Portrayals.


Talk to your healthcare provider about enrolling in Kyowa Kirin Cares to receive assistance navigating access and reimbursement options for CRYSVITA®(burosumab-twza). Once you are enrolled, you will be assigned a dedicated Case Manager who will help you understand your financial options based on your insurance coverage.

Commercial insurance

Commercial Insurance

Kyowa Kirin offers co-pay assistance for eligible commercially insured patients.a,b

Government insurance

Government Insurance

A Case Manager may be able to provide you with information about independent charitable foundation available programs that may help.c

No insurance

No Insurance

Kyowa Kirin offers a Patient Assistance Program for eligible uninsured patients.c,d

For people with government insurance

Through independent organizations outside of Kyowa Kirin, you may be able to receive additional support, such as:

  • Help with monthly premiums
  • Assistance with annual deductibles
  • Reduced costs for brand-name drugs
  • Assistance with Medicare costs

To learn more:
Call 1-800-MEDICARE(1-800-633-4227; TTY users call 1-877-486-2048) or visit

  1. a Patients must be US residents with an active primary commercial plan; patients with federal or state government insurance such as Medicare, Medicaid, and Tricare are not eligible for co-pay assistance. Other terms and conditions may apply.
  2. b Commercially insured patients do not need to participate in Kyowa Kirin Cares to be eligible for co-pay assistance.
  3. c Patients who do not meet the Patient Assistance Program coverage criteria and have special circumstances of financial and/or medical hardship, as determined in accordance with Kyowa Kirin Cares criteria, can request that an exception be made for them. The decision to grant an exception is based on an individual’s unique circumstances and is made solely at the discretion of Kyowa Kirin.
  4. d Patients must be US residents with no active medical or pharmacy benefit coverage and an annual gross income ≤400% of the federal poverty level, as confirmed by documented proof of income.

Call 833-KK-CARES (833-552-2737)
Monday through Friday, 8 AM to 8 PM (ET)


Kyowa Kirin Cares is committed to supporting you throughout your journey with CRYSVITA.

Your dedicated Case Manager can support you by:

Answering general questions about CRYSVITA

Helping you stay on track with your treatments

Providing education tools and resources

Calling routinely to check in and offer support

Work closely with your Kyowa Kirin Cares Case Manager and healthcare provider to ensure you are receiving the support you need throughout your journey with CRYSVITA.


Access Kyowa Kirin Cares forms as well as useful CRYSVITA information and resources.

Support brochure

Download this Kyowa Kirin Cares brochure and use it as a quick reference for program offerings.

Doctor discussion guide

Use this resource to guide conversations about CRYSVITA with your healthcare provider


Visit the CRYSVITA website to learn more about how CRYSVITA works, and details around the CRYSVITA injection schedule.


CRYSVITA is a prescription medicine used to treat:

  • Adults and children 6 months of age and older with X-linked hypophosphatemia (XLH)
  • Adults and children 2 years of age and older with fibroblast growth factor 23 (FGF23)–related hypophosphatemia in tumor-induced osteomalacia (TIO) when the tumor cannot be located or removed

Important Safety Information

You should not take CRYSVITA if:

  • You take an oral phosphate supplement and/or a specific form of vitamin D supplement (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
  • Your phosphorus levels from a blood sample are within or above the normal range for age.
  • You have kidney problems.

What is the most important information you should know about CRYSVITA?

  • Some patients developed allergic reactions (e.g., rash and hives) while taking CRYSVITA. Your doctor will monitor you for symptoms of an allergic reaction while you are taking CRYSVITA.
  • High levels of phosphorus in the blood have been reported in some patients taking CRYSVITA. This may be related to a risk of high calcium levels in the kidneys. Your doctor will collect blood samples to monitor your levels.
  • Administration of CRYSVITA may result in reactions at the injection site, such as hives, reddening of the skin, rash, swelling, bruising, pain, severe itching of the skin, and collection of blood outside of a blood vessel (i.e., hematoma).
  • If you are taking CRYSVITA for TIO, your doctor will have you stop your CRYSVITA treatment temporarily if you are undergoing treatment for your tumor (e.g., surgical removal of the tumor or radiation therapy).

What are the possible side effects of CRYSVITA?

  • Adverse reactions that were seen in children with XLH are:
    • Fever
    • Injection site reaction
    • Cough
    • Vomiting
    • Pain in arms and legs
    • Headache
    • Tooth abscess
    • Dental cavities
    • Diarrhea
    • Decreased vitamin D levels
    • Toothache
    • Constipation
    • Muscle pain
    • Rash
    • Dizziness
    • Nausea
  • Adverse reactions that were seen in adults with XLH are:
    • Back pain
    • Headache
    • Tooth infection
    • Restless legs syndrome
    • Decreased vitamin D levels
    • Dizziness
    • Constipation
    • Muscle spasms
    • Phosphorus levels increased in the blood
  • Narrowing of the spaces within the spine is common in adults with XLH, and pressure on the spinal cord has been reported in adults taking CRYSVITA. It is not known if taking CRYSVITA worsens the narrowing of the spaces within the spine or the pressure on the spinal cord.
  • Adverse reactions that were seen in adults with TIO are:
    • Tooth abscess
    • Muscle spasms
    • Dizziness
    • Constipation
    • Injection site reaction
    • Rash
    • Headache

Before taking CRYSVITA, tell your doctor about all of your medications (including supplements) and medical conditions, including if you:

  • Are taking oral phosphate and/or active vitamin D (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
  • Are pregnant, think you may be pregnant, or plan to become pregnant. There is not enough experience to know if CRYSVITA may harm your unborn baby. Report pregnancies to the Kyowa Kirin, Inc. Adverse Event reporting line at 1-844-768-3544.
  • Are breastfeeding or plan to breastfeed. There is not enough experience to know if CRYSVITA passes into your breast milk. Talk with your doctor about the best way to feed your baby while you receive CRYSVITA.

While taking CRYSVITA, tell your doctor if you experience:

  • An allergic reaction such as rash or hives
  • A rash, swelling, bruising, or other reaction at the injection site
  • New or worsening restless legs syndrome

These are not all the possible side effects of CRYSVITA. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at (800) FDA-1088 or You may also report side effects to Kyowa Kirin, Inc. at 1-844-768-3544.

For important risk and use information, please see the full Prescribing Information